Senior Scientist

In vivoSenior Scientist, OncologySmall Molecules

Waltham, MA

This Opportunity:

We are seekinga highly motivated Senior Scientist with a track record of scientific excellence inin-vivopharmacology to join our Oncology Small Molecules team in Waltham MA USA. As a Senior Scientist, you will be leading from the bench delivering in vivo pharmacology data to support our oncology small molecules portfolio, with a focus on drugs targeting Breast, Ovarian, Lung and Colorectal cancers.

Key Responsibilities:

• Use in vivo technical skills to support our oncology platform by:

• Working hands-onin the lab developing and working with various in vivo models of cancer including subcutaneousand orthotopic xenograft models andPatient Derived Xenograft models.

• Designing and executingin vivo pharmacology studies (tolerability, PKPD, and efficacy) and delivering comprehensive in vivo pharmacology data packagesto support early and late-stage drug discovery programs.

• Profiling of tissue samples to explore mechanisms of drug response and resistance using both traditional and novel approaches.

• Work collaboratively across disciplines to develop and implement aggressive work plans and timelines.

• Demonstrate proficiency and flexibility in working with various programs and databases to capture all study data for broad access by project teams and stakeholders.

Essential requirements: 

• BS/MS with 5+ years’ experience or PHD with 2+ years of experiencein biology, pharmacology, or related field with a minimum of 2 years “hands-on”in vivo experience.

• Practical in vivo experience and experimental skills in the use of mouse models.

• Ability to work both independently as well as within project teams and across disciplines such as DMPK and translational medicine.

• Exceptional communication, listening and organizational skills. Ability to analysis, organize and present data in an appropriate manner for a given audience.

• Understanding of statistical methodsand quality control of data.

• Familiarity withGraphPad Prism, Microsoft Office, andin vivo data capturing systemssuch as Study Log.

Additional experience desired:

• Industry experienceleading strategic and technical in vivo delivery to advancedrug discovery/development.

• Experience measuring biomarkers in blood and tissue samples using techniques such as IHC, Western blot, ELISA and MSD-based platforms. 

• Experience using small animal imaging modalities such as IVIS to monitor bioluminescence.

Location: Our Waltham site is just a short drive from Boston, equipped with state-of-the-art technology and facilities designed to boost innovation and collaboration. Enjoy amenities like a fitness center, full-service cafeteria, and more, with a shuttle bus to and from Alewife station.

Why AstraZeneca?

At AstraZeneca, we are dedicated to following the science and making a difference in the lives of patients globally. We offer competitive salaries, comprehensive benefits, and a dynamic work environment that promotes personal growth and development.

Where You Can Learn More

·Follow AstraZeneca on LinkedIn

·Follow AstraZeneca on Facebook

·Follow AstraZeneca on Instagram

Benefits

We offer a competitive Total Reward program, including:

·Competitive base salary, annual bonus, and long-term incentives

·Generous paid time off program

·Comprehensive benefits package

Diversity and Inclusion at AstraZeneca
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive team that represents a diverse group of backgrounds and perspectives, knowing that inclusion drives better outcomes.We welcome all qualified candidates and align with applicable laws regarding inclusivity and employment eligibility. Individuals with disabilities can request reasonable accommodations during the application or interview process, as well as for essential job functions.

Join Us: At AstraZeneca, we're committed to making a difference. Be part of a team that's dedicated to creating a future where science brings hope to patients all around the world. We're excited about our upcoming move to Kendall Square/Cambridge in 2026, and we want you to be a part of this journey.