MSAT Scientist, Purification

Are you ready to turn rigorous lab science into reliable, high‑yield commercial purification that gets medicines to people faster? This role sits at the heart of how we scale, stabilize, and continually improve biologics manufacturing, linking deep technical work with real‑world impact for patients with severe, underserved conditions.

You will join a team that moves with urgency and purpose, tackling complex challenges from process robustness to cost‑of‑goods improvement. From lab benches to the manufacturing floor, you will own studies that strengthen process understanding, de‑risk new product introductions, and drive measurable performance gains. How will you use DOE, scale‑up studies, and on‑the‑floor execution to increase yield and reliability across the product lifecycle?

Accountabilities:
- Lab Study Leadership: Lead, design, and execute lab studies that enhance process robustness, optimize purification performance, and characterize commercial processes; assess new materials and technologies to drive yield and cost‑of‑goods improvements that scale reliably and meet regulatory expectations.
- Scale-Up and New Product Introductions: Support large‑scale scale‑up and NPIs by leading and executing studies, including dropout studies from engineering and technical batches; translate learnings into clear recommendations that raise the probability of technical success while minimizing risk.
- Technical Troubleshooting and Investigations: Provide expert support to commercial operations; design and run experiments to resolve purification deviations, perform root cause analyses, define and implement CAPAs, and generate data for regulatory changes.
- Cross-Functional Alignment: Collaborate with manufacturing, QA, process development, and regulatory partners to align on goals, timelines, and resource plans for efficient, strategic execution of MSAT lab and plant activities.
- Data Analytics and Reporting: Analyze complex datasets, interpret results, and deliver clear technical reports and presentations that inform decisions across teams.
- Plant Study Execution: Generate documentation and protocols; lead execution of plant support and technical studies on the manufacturing floor at commercial scale.
- Statistical Rigor: Apply statistical tools, including Design of Experiments and software such as JMP, to design robust studies and make data‑driven assessments.
- Lifecycle Ownership and Regulatory Engagement: Maintain deep knowledge of product and process history across the commercial lifecycle; present and defend scientific approaches in writing and in person, including during regulatory inspections or information requests.
- Compliance and Safety: Ensure adherence to EHS, cGMP, and all applicable regulations; participate in risk assessments, audits, and incident investigations.
- Flexibility to Deliver: Support ongoing lab studies by working periodically outside normal business hours or on weekend rota when needed to protect timelines and patient supply.

Essential Skills/Experience:
- Lead, design and execute lab studies to support the robustness, process optimization, and characterization of the manufacturing processes, while assessing continual improvements, new material and technology introductions, feasibility assessments that support yield/process improvement initiatives and cost of goods improvement projects that can be replicated robustly at commercial scale, in line with regulatory and commercial manufacturing requirements, including industry best practices.
- Support large-scale manufacturing scale-up activities and New Product Introductions including leading, designing and executing studies such as dropout studies from large scale engineering and technical batches, increasing process knowledge, providing recommendations, and problem solving to increase probabilities of technical success, while minimising technical risks.
- Provide technical expertise and troubleshooting for manufacturing processes. Design and execute experiments which support process investigations, and resolution of Purification process deviations, root cause analysis, and CAPAs to support commercial operations, and studies in support of regulatory changes.
- The candidate must possess critical thinking skills, being entrepreneurial, with an ability to integrate data and information to solve complex problems to maintain robust and improved manufacturing processes. Effectively communicate complex ideas to audiences with varying degrees of knowledge.
- Collaborate cross-functionally to align on study goals, timelines, and project planning to ensure efficient and strategic execution of MSAT Lab activities.
- Analyse complex datasets, interpret results, and prepare detailed technical reports and presentations to cross-functional teams.
- Generate documentation protocols and lead the execution of plant supporting studies and technical studies on the manufacturing floor at commercial scale.
- Apply statistical tools such as Design of Experiments (DOE) using software such as jmp to drive robust experiments and data-driven technical assessments.
- Maintain knowledge and history of the products and process throughout the entire commercial lifecycle, inclusive of development history.
- May be required to present/defend technical and scientific approaches in both written and verbal form, including during regulatory agency inspections or information requests.
- Ensure compliance with site EHS policy, cGMP and other business regulations and participate in risk assessments, audits, and incident investigations.
- May be required to work periodically out of normal business hours or participate in weekend rota to support ongoing lab studies.

Desirable Skills/Experience:
- Practical experience with downstream purification unit operations (e.g., chromatography, ultrafiltration/diafiltration, viral clearance) at pilot and commercial scale.
- Hands-on involvement in technology transfer from development to commercial manufacturing.
- Familiarity with process economics and cost‑of‑goods modeling to guide optimization choices.
- Experience contributing to regulatory submissions or responses for manufacturing changes.
- Advanced analytics capability (e.g., JMP scripting, multivariate analysis) to enhance study design and insight generation.
- Proven track record leading cross‑functional initiatives that delivered yield, robustness, or cycle‑time improvements.

Why AstraZeneca:
Here, science meets urgency to change the trajectory of rare and devastating diseases. You will feel the energy of a nimble biotech backed by the scale and stability of a global biopharma—unexpected teams in the same room unleashing bold thinking, rapid iteration, and decisive execution. We stay close to patients and to one another, so your lab studies and on‑the‑floor work translate quickly into outcomes that matter. Expect autonomy with support, tailored development that grows both your technical depth and your judgment, and a culture that values kindness alongside ambition as we turn difficult problems into meaningful progress.

Call to Action:
Step into this MSAT role and transform smart experiments into dependable commercial purification that speeds life‑changing medicines to patients—make your move today!

Date Posted

30-Jan-2026

Closing Date

13-Feb-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.