In vivo Senior Scientist Hematology Oncology

This Opportunity:

We are seeking a highly motivated Senior Scientist in cancer pharmacology with a track record of scientific excellence in the area of in vivo pharmacology, to join our team in Waltham MA USA. As a Senior Scientist you will be leading from the bench and a member of the in vivo team focused on delivering in vivo pharmacology datasets that will have direct impact on the drug discovery process and pipeline.

Key Responsibilities:

• Use in vivo technical skills to support our oncology platform by:
  • Working hands-on in the lab developing and working with various in vivo models of cancer including subcutaneous xenograft models, disseminated models, PDX models and humanized models.
  • Conducting in vivo pharmacology studies (tolerability, PKPD, and efficacy) and delivering comprehensive in vivo pharmacology data packages to support early and late-stage drug discovery programs.
  • Profiling of tissue samples to explore mechanisms of drug response and resistance using both traditional and novel approaches.
• Demonstrate proficiency and flexibility in working with various programs and databases to capture all study data for broad access by project teams and stakeholders.
• Work collaboratively across disciplines to develop and implement aggressive work plans and timelines.

Essential requirements:

• MS with 4+ years’ experience or PHD with 2+ years of experience in biology, pharmacology, or related field with a minimum of 2 years “hands-on” in vivo experience.
• Practical in vivo experience and experimental skills in the use of mouse models
• Ability to work both independently as well as within project teams and across disciplines such as DMPK and translational medicine.
• Exceptional communication, listening and organizational skills. Ability to analysis, organize and present data in an appropriate manner for a given audience.  
• Practical In vivo experience and experimental skills in the use of animal models.
• Must have foundational experience in molecular and cellular biology techniques including Flow cytometry, Western Blot platforms, RT-PCR platforms, ELISA/MSD, and assay development troubleshooting skills.
• Understanding of statistical methods and quality control of data.  
• Familiarity with in vivo database capturing systems ie Study Log or a similar program, Prism GraphPad and Microsoft suit.

Additional experience desired:

• Experience with orthotopic xenograft, humanized models and disseminated hematologic cancer models including tissue collection and necropsies.
• Experience with spectral flow cytometry is highly desirable.
• Ability to design flow panels and analyze biomarkers in blood and tissue samples using MACSQuant and/or BD instruments and analysis in FlowJo and Omiq.

The annual base salary (or hourly rate of compensation) for this position ranges from $109,301 to $163,952. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.