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Associate Principal Scientist, Flow Cytometry

Ort Waltham, Massachusetts, USA Anzeigen-ID R-197225 Veröffentlichungsdatum 12/04/2024

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue premier medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe. As a part of our Dynamic Omics team, you’ll play a pivotal role in channelling our scientific capabilities to make a positive impact on changing patients’ lives.

Summary of the Group

The Flow Cytometry group is part of Dynamic Omics/ Centre for Genomics Research (CGR) and Discovery Sciences within AstraZeneca and works across all therapeutic areas including Oncology; Cardiovascular, Renal and Metabolism (CVRM); Respiratory and Immunology (R&I); Vaccines and Immunotherapies (V&I); Neurosciences, and Rare Diseases. Our team supports over 450 scientists globally and delivers key data to projects across all phases of the drug discovery and development. We work across all modalities from small molecules to biologics. The Global Flow Cytometry Center of Excellence is among the leading flow cytometry organizations in the US and UK, and includes state-of-the-art instrumentation equipped with cutting-edge technology and the requisite expertise.

What you’ll do

In this role, you will support the operations of the team initially in Waltham, MA, and participate in collaborations with multiple therapeutic areas. In 2026, the team will relocate to Kendall Square in Cambridge to our new Boston R&D headquarters. The successful candidate will have the opportunity to work and grow in a fast-paced environment under the supervision of senior staff members.

In this role, you will serve as a primary resource to:

·       Oversee and drive daily and long-term flow cytometry operations in conjunction with local flow cytometry and site leaders to ensure proper maintenance of the instruments and training of the new hires, aligned with global flow cytometry leadership

                •              Provide support for drug discovery projects through assistance with experimental design, flow cytometry techniques, and data analysis for pre-clinical and clinical studies

                •              Oversee development of innovative projects; contribute to practical delivery of project goals by providing expert advice and interpreting complex data

·       Demonstrate excellent collaborative efforts with multiple therapeutic areas focusing on innovative immunology/flow cytometry projects and automation solutions to meet overall strategic objectives

·       Demonstrate excellent proactive problem-solving skills to identify issues, take appropriate actions and seek guidance when needed

·       Summarize data for presentations, reports, and publications with accountability for accuracy. Review and approve flow cytometry data and reports to ensure quality and integrity

·       Demonstrate broad understanding of current and emerging technologies in cellular analyses, with a keen perspective of how novel approaches might fit across each of the supported Therapeutic Areas

·       Ensure own work, and work of team, is aligned with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulation

·       Ability to gain trust from key collaborators in the Therapeutic Areas

Education & Experience Requirements:

·       PhD degree (or equivalent experience) in Immunology, Bioinformatics, Engineering or a related quantitative discipline with 5+ years of experience, or a Master with +8 years of directly relevant outstanding performance

Essential Criteria

·       Experience with setting goals and objectives, motivating and developing scientists is highly desirable

·       Well-developed understanding of flow cytometry, cell sorting and immunology, following best industry practises

·       Experience with a variety of flow cytometry data analysis and bioinformatic tools, including FlowJo, FCS Express, OMIQ, Cytobank and/or programming with Python or R

·       Lead collaborations and advance projects by standardizing the design of experiments, analysis and interpretation of data from of our preclinical and clinical studies, and summary of experimental results for presentations, review for accuracy and write reports and high-quality/high impact scientific publications

·       Strong multi-tasking, time management, organizational skills and excellent communication skills, both verbal and written 

Desirable Criteria

·       Experience with multiomic integration and working with data scientists creating data analysis platforms is highly desirable

·       Significant experience in the pharmaceutical industry and drug discovery process

·       Experience with establishing automated lab processes is desirable

·       Microscopy experience is a plus 

Why AstraZeneca

 Make a significant impact to patients’ lives around the globe

At AstraZeneca, we 're dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and ignite your Entrepreneurial ambitious spirit. There’s no better place to make a difference in medicine, patients, and society. An inclusive culture that champions diversity and teamwork. Always committed to lifelong learning, growth, and development. 

AstraZeneca in Boston, MA

Our Waltham, Massachusetts facility develops life changing small-molecule and biologics research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world’s most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release

At AstraZeneca, we are on a mission to eliminate cancer as a cause of death. As part of our Oncology R&D team, you will be at the forefront of applying science to studies and using innovative approaches to create new possibilities. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. Our commitment to patients and pioneering spirit are truly embedded and it's what makes our pipeline unique. With varied and interesting problems to solve, we get a constant thrill from the challenge. We benefit from global interactions with top experts across the world, giving us an incredible support network. By working with diverse functions, we get exposure to multidisciplinary learning and diverse perspectives.

Ready to make a difference? Apply now!

 Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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