Senior Scientist – Biocatalysis

Job Title: Senior Scientist – Biocatalysis

Macclesfield

Introduction to role:

Join our Early Chemical Development group as a Senior Scientist - Biocatalysis, where you'll be part of a team that transforms molecules into investigative medicines. Our work spans from early engagement with Discovery Chemistry groups to the manufacture of Phase II Clinical material. We're looking for a dedicated scientist to be a key member of the biocatalysis team, bringing a strong understanding of applied biocatalysis to the design and development of robust enzymatic processes for the manufacture of drug substances.

Accountabilities:

As a lab-based scientist, you will identify, develop and scale-up processes throughout the portfolio by finding opportunities for the application of enzymes in drug substance manufacturing. You’ll perform screening for selected opportunities, develop and implement reactions at multi-gram scale to enable early manufacturing either in-house or via outsourced work at CMOs/CROs if appropriate. You will also contribute to the success of AZ’s biocatalysis team, maintain up-to-date knowledge of technical advances in biocatalysis, and deliver enzymatic steps for drug substance manufacturing according to project timelines.

Essential Skills/Experience:

• Degree, advanced degree or equivalent scientific qualification in a relevant subject area
• Proven experience of biocatalysis with a track record of delivery and creativity Proven problem solver with in-depth technical skills
• Functional expertise in applying biocatalysis at gram scale and using synthetic organic chemistry to make substrates/standards as appropriate
• Knowledge and application of analytical chemistry and assay selection/development such as MS, ELSD, NMR and other techniques required to evaluation enzyme performance
• Understanding and practice of applying GLP and SHE working in the laboratory
• Excellent written and verbal communication skills in English

Desirable Skills/Experience:

• An awareness of green chemistry and sustainability principles and tools and their application towards the development and manufacture of drug substances
• Understanding of the overall drug development process from discovery through to launch
• Experience of discovery and early development phases of the drug development process and the contribution Pharmaceutical Development makes to the development and launch of medicines

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. This is a lab based role working five days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?

Join us at AstraZeneca's Biopharmaceuticals R&D unit where we are unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference by fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.

Are you ready to follow the science and be part of a team that makes a bigger impact on patients' lives? If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be. Apply now and join us in our mission to push the boundaries of science to deliver life-changing medicines!

We encourage your application before 17th May 2024 and will be reviewing applications as and when they come through to us.