Scientist – Particle Characterisation (12 Months FTC)

Scientist – Particle Characterisation (12 Months FTC)

Macclesfield UK (5 days on-site)

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical company where we not only focus on the discovery, development and delivery of life-saving medicines to our patients but believe in sustainability and are determined to minimise the impact of our work on the environment. We are proud to be a phenomenal place to work and have a culture that encourages innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity.

Come and join our AZ team where you will play a pivotal role in this exciting period of development!!

Join our Particle and Process Engineering Team in ECD based in Macclesfield UK as a Scientist. We are looking for an enthusiastic, motivated and highly capable individual who can work closely with cross functional teams including chemists and many other scientists within the drug product units to contribute to Pharmaceutical Science projects. You will be involved in supporting the characterisation of novel active pharmaceutical ingredients (API) with a focus on ensuring the right quality API physical attributes, meaning particle properties are met or associated risks are suitably handled.

You may also have the opportunity to plan and drive improvement projects, use new techniques or modify our ways of working within AstraZeneca or externally with our Contract Development and Manufacturing Organisations (CDMOs).

Key Responsibilities:

• Applies a wide range of materials characterisation techniques for the development and manufacture of Drug Substances.

• Develops an understanding of the link between critical physical attributes, process robustness and performance, including the impact of Drug Substance particle property variability at the Drug Substance/Drug Product interface.

• Is responsible for the assessment of API physical attributes risks, development and delivery of Drug Substance to Drug Product Departments via clear plans and strategies to support drug projects.

• Ensures timely and accurate reporting, analysis and interpretation of data. Be responsible for the authoring of development reports, and contributions to regulatory documentation as required.

• Works as a member of cross-functional teams, with a large degree of independence representing Drug Substance Materials Science on project teams. Collaborative working is encouraged with specialists in areas such as chemistry, engineering, analytical, crystallisation science, solid state, biopharmaceutics and formulation to build process understanding from an API perspective.

• Reviews and coordinates appropriate Drug Substance Material Characterisation methodology and specifications for these.

• Works closely with our colleagues in Supply Chain and our Contract Development and Manufacturing Organisations (CDMOs) across the globe, providing input in terms of API/material science/physical attributes into process development.

• As a member of a global department and network, identifies, evaluates and implements state of the art characterisation approaches to build and improve API material science capability.

• Develops links with external collaborators to advance API material science capability.

• Ensures own work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP)

Requirements:

• Degree (BSc) in Material or Particle Science or a related subject. Equivalent experience will be considered.

• Experience of techniques used to investigate particle properties such as Particle Size Distribution, flow, bulk properties and broader awareness of material science areas such as colloid and interface science, soft matter characterisation, imaging, etc which can be applied to any APIs.

• Understanding of how to develop relationships between API physical/material attributes and product processing/product performance.

• Experience and motivation for Laboratory work.

• Have the ability to work collaboratively with colleagues in Drug Product Development in multi- functional teams to define particle properties for formulations, manufacturability and bioavailability.

• Ability to seek complex scientific problems and troubleshooting.

• Excellent communication and partner engagement skills, and the ability to discuss complex ideas in a simple, easy to understand way.

• Generating, reporting and interpreting high quality data with clear impact to development projects.

• Ensuring own work is performed and recorded in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Manufacturing Practice (GMP).

Desirables:

• Knowledge and industrial experience of pharmaceutical development.

• Knowledge of processes used for Drug Substance and Drug Product manufacture.

• Understanding of solid-state properties that are linked to material behaviour

• Knowledge of particle size reduction unit operations.

• Influencing skills and prioritisation skills to ensure project delivery

• Involvement with working with Contract Development and Manufacturing Organisations (CDMOs).

• Involvement in the development and manufacturing of non-crystalline or large molecule entities.

In Office Requirement:

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of five days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?

At AstraZeneca's Oncology R&D business area, you'll be part of a team playing a critical role in driving meaningful change in the way we predict, prevent and treat patients' conditions. We're actively embracing and investing in technology, harnessing digital, data and analytics to reimagine the future of healthcare and deliver improved outcomes to patients beyond core medical. We're shaping the future, improving and speeding up portfolio development, improving the patient experience and outcomes at clinical trials. Join the team that is co-creating a digital ecosystem with patients at its core.

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, colour, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.