Formulation Senior Scientist, Tumour Targeted Delivery, Oncology R&D

Join us in our mission to eliminate cancer as a cause of death. We are seeking a laboratory-based formulation scientist to join our Bioconjugation group in Tumour Targeted Delivery (TTD) at our Chemistry Site in London, UK. This role offers the opportunity to contribute to the research and development for early phase projects within our Oncology portfolio. You will play a pivotal role in the delivery of robust and high-quality data to support drug discovery projects.

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Site description

Our TTD-Chemistry site situated in Whitechapel, London is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you After-work events, Lunch & Learns, spacious balanced office working environment. Situated in the heart of London’s historical east end close to the fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.

Business area

Take our leading Oncology pipeline to the next level! Working with one of the broadest and deepest Oncology pipelines in the industry offers the possibility to work on the most novel molecules at all development stages. It takes each of us challenging our thinking to keep pushing our pipeline forward and craft the future of Oncology. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office.

What you’ll do

As a Formulation Senior Scientist, you will use your scientific judgement to develop colloidally and conformationally stable formulations of conjugated biologics. You will perform biophysical characterisation and associated stability studies, analyse and interpret experimental data, and contribute to decision making for early-stage drug discovery programmes.

Essential for the role

• Ph.D in Chemistry, Biochemistry, Bio/Chemical engineering, Pharmaceutical Sciences or relevant discipline

• M.Sc or B.Sc in above disciplines with relevant industrial experience

• Experience with formulation strategies, purification, biophysical characterization and stability testing of proteins/conjugates

• Knowledge of antibody and/or general protein sequence and structural analysis

• Strong background in chemistry and protein biochemistry

• Hands on experience of performing a range of protein/bioconjugate characterisation by Dynamic Light Scattering (DLS), Differential Scanning Calorimetry (DSC), size-exclusion/hydrophobic interaction/ion exchange chromatography HPLC, cIEF, ceSDS, nephelometry, UV/Vis spectroscopy, and LCMS

• Experience with executing preparative chromatography purifications using AKTA and TFF systems

• Knowledge and strong understanding of developing and optimising robust analytical methods for antibody drug conjugate/protein related conjugates characterisation might be beneficial

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.

So, what’s next?

• Ready to make a difference? Apply now and join us in our mission to eliminate cancer as a cause of death.

Competitive salary package and benefits

Close Date: 27/05/2024

Where can I find out more?

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