Thesis work, 30 credits - Peptide-Based Drug Development in Separation Science Lab

Are you passionate about peptide-based drug development? Do you want to be at the cutting edge of pharmaceutical research? Join our innovative research team at the Separation Science Lab and immerse yourself in the captivating world of liquid chromatography! 

About AstraZeneca: 

AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world’s most serious diseases. But we’re more than a global leading pharmaceutical company. At AstraZeneca, we're dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit.  

About the Opportunity: 

As a Thesis Worker at AstraZeneca, you’ll find an environment that’s full of unique opportunities and exciting challenges. Here, you’ll have the opportunity to pursue your areas of interest whilst equally developing a broad skillset and knowledge base to get the best out of your experience. You’ll be working on meaningful projects to make an impact and deliver real value for our patients and our business. 

Thesis work description:  

This project focuses on exploring the orthogonality between Hydrophilic-Interaction Liquid Chromatography (HILIC) and Reversed-Phase Liquid Chromatography (RP) for the analysis of impurities in synthetic peptides. You will work collaboratively with our team of experts to decode the complex interactions between these chromatographic techniques, playing a vital role in enhancing the quality and sustainability of peptide synthesis — a pivotal advancement in the pharmaceutical industry. 

Key Objectives: 

• Utilize HILIC and RP as orthogonal techniques to improve impurity analysis of synthetic peptides. 
• Develop innovative methodologies that will contribute significantly to quality control and purification processes. 

Research Details: 

Synthetic peptides are crucial candidates in drug development and are integral parts in oligonucleotide-conjugates, giving guiding functions of oligonucleotides. As the length of peptides increases, so does the complexity and number of impurities, presenting a significant challenge in chromatographic analysis and purification. 

Traditionally, RP chromatographic methods are considered the gold standard; however, HILIC remains largely underexplored despite its potential in managing complex peptide analysis. In this project, you'll evaluate and optimize various chromatographic techniques and parameters for scale up to purification methods. You will also engage in advanced mass spectrometric analysis to identify and analyze impurities, as well as collaborate closely with our peptide chemistry team to develop strategies for improved peptide synthesis. 

Essential Requirements: 

• Ongoing master’s studies within Pharmacy, Engineering, or equivalent. 
• BSc in chemistry, analytical chemistry or similar 
• Practical lab skills in analytical and/or preparative separation science 
• Problem-solving mindset  
• Scientific communication 

So, what’s next?  

Apply today and take the chance to be part of making a difference, making connections, and gaining the tools and experience to open doors and fulfil your potential. We can´t wait to hear from you!  

We welcome your application as soon as possible, but ahead of the scheduled closing date 4th of May 2025. In the event that we identify suitable candidates ahead of the scheduled closing date, we reserve the right to withdraw the vacancy earlier than published.