Thesis work 30 credits: Develop and validate a pre-clinical Pig model in GI-Sim

Are you passionate about Life Science and want to contribute to life changing research? Then take the chance to perform you master thesis with us at AstraZeneca!

Project description:
The AZ developed physiological based biopharmaceutic model (PBBM) GI-Sim, is frequently used to assess the interplay of various biopharmaceutics properties of different APIs and formulations during drug development. The GI-Sim tool incorporates both pre-clinical models (rat, dog, mouse) and human models (fed & fasted). During the last few years, the pig has become an often used pre-clinical species in PK and tox studies and hence the development of a pig model in GI-Sim is highly needed.

During this Master thesis you will review the literature and collect data on the physiology of the pig, i.e. GIT volumes, transit times, permeability, micelle concentrations etc. Based on the collected data the student will build a Pig model(s) in GI-Sim and validate the model(s) with in-house PK data from previous studies. 

Essential Requirements:

• Ongoing Master studies in relevant area - pharmaceutics, bioscience or similar.

So, what’s next?
Apply today and take the chance to be part of making a difference, making connections, and gaining the tools and experience to open doors and fulfil your potential. We can´t wait to hear from you!

Last application date: 2024-05-31

Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.