Senior Scientist

Senior Scientist

Introduction to role

We are seeking a highly motivated Senior Scientist with extensive expertise in cancer immunology/immunotherapy. The successful candidate will have substantial experience in studying T cells and myeloid cells both in vivo and in vitro, with a specific interest in myeloid cell progenitors and/or lipid metabolism. You will independently design and execute projects/experiments, troubleshoot and optimize methods, and generate, interpret, and report scientific data clearly and concisely. A PhD in Immunology or a related field and a proven postdoctoral record with strong publications are required. Strong expertise with mouse tumor models is desirable.

As a Senior Scientist in our Oncology R&D department, you will be a key member of a team focused on designing novel therapeutics to target myeloid biology and immunotherapy, supporting projects through the drug discovery and development process. You will bring your theoretical and practical expertise in immunology to establish assay systems and deliver datasets that will have a direct impact on immune-oncology therapeutics.

Accountabilities

• Independently conduct cancer immunology and drug discovery research experiments using techniques in immunology, molecular, and cellular biology

• Assess and report data with little guidance in a clear and concise manner with a strong understanding of its implications within the overall context of drug discovery

• Maintain a well-developed understanding of approaches to investigate the function of myeloid cells and aspects of drug discovery

• Actively liaise between programs/departments, sharing scientific knowledge and feedback on others’ experiments to ensure efficient relay of information and translation of data

• Ensure own work and work of peers is compliant with Good Laboratory Practice, Safety, Health, and Environment standards, and all other relevant internal AstraZeneca standards and external regulations

• May be asked to lead or co-lead a project team and contribute to scientific publication goals

Essential Skills/Experience

• A PhD and 2+ years of relevant experience in immunology and cancer biology is required

• Extensive experience in studying T cells or myeloid cells: MDSC, macrophages, dendritic cells, expertise or knowledge of peptide vaccines

• Strong hands-on skills in basic biochemical and immunological methods including multi-color flow cytometry (FACS), ELISA/multiplex assays, western blotting, luminescence assays, cell killing assays, high content imaging

• Excellent organizational and communication skills

• Ability to work in a high-paced team environment, plan and meet timelines

• Proven track record of success in your research, and experience preparing written scientific reports (e.g., manuscripts) and oral presentations to broad and diverse audiences

Desirable Skills/Experience

• In vivo expertise in murine tumor models

• Experience developing cancer immunotherapy including cancer vaccines and cellular therapies

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace, and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we follow the science and pioneer new frontiers. Join our team dedicated to Oncology with an ambition to eliminate cancer as a cause of death. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing cutting-edge science with the latest technology to achieve breakthroughs. Backed by investment, we aim to deliver 6 new molecular entities by 2025. Our environment is built on courage, curiosity, and collaboration. We make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team. Pioneers of collaborative research, we have built an unrivalled scientific community both internally and externally. Working seamlessly together, we expedite research in some of the hardest-to-treat cancers. Have the opportunity to build a rewarding career as part of the team committed to improving the lives of millions with cancer.

Ready to make a difference? Apply today!

The annual base pay (or hourly rate of compensation) for this position ranges from $108,474 to $162,710. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.