Associate Director, In Vivo Pharmacology, Oncology R&D

Associate Director, In Vivo Pharmacology, Oncology R&D

Are you ready to make a difference in the world of Oncology? We are seeking a pharmacology Associate Director within the Oncology Targeted Delivery (OTD) group to serve as an in vivo lead and leader supporting both preclinical and clinical programs. This role will work with colleagues to generate robust datasets directly impacting oncology ADC drug discovery and pipeline development.

Accountabilities:
Working within the Early Oncology In Vivo Pharmacology Team, you will develop, design, and analyze both in vivo and in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will be expected to collaborate with cross-functional teams including representatives from biosciences, translational medicine, clinical, drug metabolism, pharmacokinetics, and safety to help understand the translatability of in vivo research to the clinic. You will work collaboratively with project leaders to ensure the timely generation, and dissemination of critical program data, and contribute to scientific publication goals. As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology, pharmacology and cancer modeling and have a genuine passion for this field of research.

Essential Skills/Experience:
- MS or Ph.D. in relevant field and at least 10 yrs (Ph.D.) or 15 yrs (MS) related post-degree experience
- Experience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic and orthotopic mouse models
- Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies
- In-depth knowledge of ADCs and oncology disease area biology (solid tumors); experience with both ADC and immuno-oncology assets
- Experience in preparing pharmacology project packages for internal milestone transitions and IND filings which exemplify a clear communication style
- Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca
- Highly developed problem solving and risk management skills, and attention to detail
- Strong interpersonal, collaborative and team building skills

AstraZeneca is a place where innovation thrives! Our commitment to pushing the boundaries of science empowers us to transform the lives of patients living with cancer. With one of the broadest Oncology pipelines in the industry, we offer unparalleled opportunities to work with novel drugs and make bold moves that truly improve patient outcomes. Our collaborative environment fosters courage and curiosity, enabling us to take smart risks and challenge the norm. Join us in our mission to eliminate cancer as a cause of death by applying cutting-edge science and interdisciplinary approaches.

Ready to make an impact? Apply now and be part of our journey to redefine cancer treatment!

The annual base pay for this position ranges from $158,500.80 - 237,751.20. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.