Senior Director, Enterprise Transformation

Are you ready to transform how a complex, mission-driven organization works to accelerate impact for patients with rare diseases? As Senior Director Enterprise Transformation, you will lead a lean, agile Enterprise Productivity Office to pinpoint, prove, and scale the changes that matter—simplifying work, increasing capacity, and improving delivery across our rare disease unit. Based in Ireland and reporting to the Head of Business Operations, you will partner directly with the executive team to diagnose challenges, shape enterprise strategies, and bring AI, digital and operating model solutions to life. Can you convert ambiguity into an enterprise-wide, prioritized pipeline that improves decision speed, productivity, and outcomes? In this high-visibility role, your recommendations will inform CEO- and executive-level decisions and your work will be measured by adoption and measurable value realized. Accountabilities: Enterprise Effectiveness and Productivity Strategy: Partner with executive and functional leaders to target improvements in organizational effectiveness, decision speed, productivity, operating models, location strategy, and ways of working—building a clear, high-value pipeline. Executive Advisory and Business Case Development: Diagnose ambiguous business challenges and translate them into actionable recommendations; quantify value and investment; shape prioritization and resourcing; and guide CEO/executive decision-making. AI, Digital and Data Enablement: Identify, test, and scale AI, automation, digital tools, and data-driven capabilities that raise efficiency, effectiveness, and employee experience—proving impact through pilots and extending what works. Organizational Transformation and Change: Lead operating model evolution, functional effectiveness, shared services/global business services approaches, and workforce productivity—ensuring sustainable adoption of new ways of working. Enterprise Capability Building: Create tools, frameworks, dashboards, and playbooks that enable functions to independently drive continuous improvement and measurable outcomes, reducing reliance on central teams over time. Pipeline and Value Realization: Maintain an enterprise-wide productivity opportunity pipeline; define success metrics; and track outcomes against baseline for cost, capacity, cycle time, quality, employee experience, and adoption. Stakeholder Influence and Alignment: Engage executive sponsors, functional leaders, Digital & IT, HR, Finance, and external partners to align on goals, resolve barriers, and deliver outcomes through a small, high-impact team. Team Leadership: Lead a lean EPO team with project management and finance business partnering capabilities—prioritizing ruthlessly, moving fast on proofs of value, and scaling what delivers enterprise impact. Essential Skills/Experience: - 10+ years in enterprise transformation, management consulting, business operations, organizational effectiveness, strategy, digital transformation, AI enablement, or related leadership roles. - Proven ability to partner with executive teams, diagnose ambiguous business challenges, shape solutions, and influence strategic decisions without direct authority. - Demonstrated experience developing business cases that drive enterprise value and measurable outcomes. - Experience with operating model redesign, organizational transformation, workforce productivity, location strategy, functional effectiveness, or business process excellence. - Experience identifying and implementing AI, digital, automation, or data-driven capabilities that improve organizational effectiveness. - Exceptional executive communication, stakeholder management, analytical, synthesis, and problem-solving skills. Desirable Skills/Experience: - Advanced degree in business, life sciences, engineering, data science, organizational effectiveness, or a related field. - Experience leading lean, agile transformation teams with a focus on measurable value realization. - Background in biopharmaceuticals, rare disease, or other highly regulated, science-driven environments. - Expertise in shared services/global business services design and implementation. - Familiarity with modern automation and data platforms and change leadership methodologies. Why AstraZeneca: Join a rare disease organization where bold thinking meets real-world impact for underserved patients. You will find the entrepreneurial energy of a biotech backed by the scale, investment, and stability of a global leader—unexpected teams in the same room unleashing ideas, pairing operating model innovation with AI and data to change how work gets done. We value kindness alongside ambition, encourage ownership beyond job titles, and create space to stretch into new skills while staying close to the people our work serves. Your leadership will directly connect enterprise productivity to patient outcomes and help set the pace for what comes next. Call to Action: If you are ready to turn complex challenges into executive-backed decisions and measurable enterprise value, step into this role and help redefine how our rare disease organization delivers for patients and teams.

Date Posted

27-Jul-2026

Closing Date

23-Aug-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.