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Scientist/Senior Scientist – Epigenetics and Transcription Regulation, Oncology Bioscience

Ort Waltham, Massachusetts, USA Anzeigen-ID R-074863 Veröffentlichungsdatum 02/18/2020

Scientist/Senior Scientist – Epigenetics and Transcription Regulation, Oncology Bioscience

Waltham, MA  


We are building our team in the exciting area of epigenetics and have multiple in vitro lab-based bioscience positions open in Early Oncology R&D. We are seeking highly motivated and skilled scientists to join this group.  As an In VitroScientist/Senior Scientist, you will use your technical and scientific expertise to help build our epigenetics platform through identification and validation of novel epigenetics targets, execution of novel CRISPR screens, and leading efforts in assay development, compound profiling and characterization of the mechanism of action of epigenetic therapies. Additionally, you will play a key role in supporting current epigenetic projects while collaborating with scientists across multiple functional groups. Your efforts will contribute to the delivery of candidate drugs that you may continue to work on in the clinic. 

Major Responsibilities:

These may vary depending on the position.

  • Lead efforts to identify and validate novel epigenetic targets
  • Design and execution of in vitro proof of concept studies to support the characterization and development of candidate molecules
  • Develop and implement epigenome profiling assays, including ATAC-seq and ChIP-seq to support AstraZeneca’s expanding epigenetics portfolio
  • Collaborate productively with medicinal chemists, discovery biologists, NGS scientists and bioinformaticians to integrate preclinical data

Desired Qualifications:

  • One of the following:
    • MS with 3+ years of experience in epigenetics and cancer biology
    • PhD with 2+ years of experience in epigenetics and cancer biology
  • Experience in pharmaceutical industry is a plus
  • Experience in epigenetic profiling studies, including ChIP-Seq, ATAC-Seq, is a plus
  • Adept at managing multiple priorities in an efficient and organized manner
  • Excellent track record of ability to work in a fast-paced team environment, with strong communication, organization, efficiency and leadership skills

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

  • Next Steps – Apply today!
  • To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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