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Principal Scientist and In Vivo Team Lead, Hematology Oncology

Ort Waltham, Massachusetts, USA Anzeigen-ID R-073195 Veröffentlichungsdatum 02/04/2020

Principal Scientist and In Vivo Team Lead, Hematology Oncology

Boston, MA


AstraZeneca is dedicated to discovering, developing, and delivering innovative, meaningful medicines and other healthcare solutions that help enrich the life of patients, as well as their families and communities. At AstraZeneca Oncology, our vision is redefining cancer, redefining our solutions to cancer and restoring patients' lives. 

We are looking for an in vivo pharmacologist with industry experience to join the oncology R&D Boston team at AstraZeneca, located in Waltham, MA.  As a Principal Scientist, you will provide strategic leadership to projects and manage a team of in vivo scientists to support our hematological cancer drug portfolio. This role requires a blend of drug development experience in oncology, coupled with strong people management skills and demonstration of scientific leadership. 

Key Responsibilities:

  • Manage a team of in vivo pharmacologists including PhD level scientists; provide oversight and scientific guidance of in vivo lead biologists to ensure high quality in vivo data generation including:
    • in vivo target validation and proof of concept
    • in vivo PK/PD/efficacy studies for lead optimization and drug candidate selection
    • in vivo therapeutic efficacy trials for dose and schedule optimization
    • in vivo mechanism-based combination studies to guide development of clinical assets. 
  • As a project lead biologist, provide strategic guidance and leadership of the biology team for projects through all stages of drug discovery including target validation stage to clinical proof of concept.
  • Provide in vivo pharmacology and disease model expertise across multiple projects within our drug discovery portfolio.  
  • Provide scientific mentorship, professional development, guidance and leadership to junior scientist, ensuring alignment with overall department and organizational goals.
  • Promote the scientific reputation of AstraZeneca by recruiting new postdoctoral candidates, publishing novel research in peer reviewed journals, and presenting data at scientific meetings.

Essential Requirements:

  • Ph.D. in Pharmacology or related discipline, with a minimum of 10 years industry experience.
  • Strong scientific track record of delivery, including publications in peer-reviewed journals.
  • Direct experience using mouse models of cancer to evaluate the in vivo pharmacology of small molecule drugs targeting cancer.
  • Strong scientific knowledge of oncology drug discovery including emerging concepts in cancer therapeutics.
  • Direct industry experience managing people in multi-disciplinary teams.
  • Excellent leadership, communication and organizational skills.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

  • Next Steps – Apply today!
  • To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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