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Research Scientist, Mechanistic Biology & Profiling

Ort Waltham, Massachusetts, USA Anzeigen-ID R-078735 Veröffentlichungsdatum 04/06/2020

At AstraZeneca, we’re not afraid to do things differently. We’re building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening up new ways to work, pioneering cutting edge methods and bringing unexpected teams together. As a Senior Research Scientist in the Mechanistic Biology & Profiling Group in Waltham, US, you will pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.

Discovery Sciences is a multi-faceted department which drives early drug discovery across AstraZeneca’s global Research & Development portfolio. Mechanistic Biology & Profiling (part of Discovery Sciences), is a global, multidisciplinary department responsible for mechanism-of-action studies and compound profiling for efficacy and pre-clinical safety in support of the Oncology, Cardiovascular and Renal Disease, Respiratory, Inflammation & Autoimmunity, and Neuroscience portfolios.

If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Main Duties and Responsibilities

Reporting directly to the US Associate Director of the Mechanistic Biology & Profiling Department you will be an integral member of a team generating pre-clinical pharmacology data to predict and understand compound (and novel drug modalities) efficacy.

You will provide early, impactful mechanistic insight to projects across the Oncology and Neuroscience disease areas, through a combination of in vitro enzymology, pharmacology, and quantitative cell biology. You will be a skilled and passionate lab-based scientist, able to represent the department across a range of therapeutic projects and global initiatives, and also externally. You will be involved in scientific and technical innovation, including through external collaboration and partnership.

Essential Requirements

  • PhD and some experience preferred or MSc and at least 8 years of relevant experience required
  • Formal training and proven expertise (PhD or MSc + equivalent industry experience) in a quantitative biology-based discipline (enzymology, pharmacology, quantitative cell biology)
  • Eternal reputation in pharmacology and/or enzymology, gained through professional recognition, external presentation and/or publication in high-impact journals
  • Track record of delivering results across a diverse project portfolio

Desirable Requirements

  • Experience in pre-clinical drug discovery
  • Experience of establishing and leading external collaborations


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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